How the immune system could stymie some CRISPR gene therapies

Nature   NEWS EXPLAINER 08 JANUARY 2018

Researchers hoping to use a gene-editing technique to treat diseases may have to seek alternative enzymes.

The body’s own immune system could thwart some efforts to develop gene therapies based on the trendy genome-editing tool called CRISPR-Cas9, according to a study released on 5th January.
Hopes are high that CRISPR–Cas9 could one day be used in people to correct mutations that cause disease. But the new study, which was …

U.S. doctors plan to treat cancer patients using CRISPR

MIT Technology Review by Emily Mullin January 17, 2018

Gene-edited immune cells could help wipe out deadly tumors.

The first human test in the U.S. involving the gene-editing tool CRISPR could begin at any time and will employ the DNA cutting technique in a bid to battle deadly cancers.

Doctors at the University of Pennsylvania say they will use CRISPR to modify human immune cells so that they become expert cancer killers, according to plans …

What is CRISPR gene editing, and how does it work?

by Merlin Crossley | 3 Feb 2018

What is CRISPR gene editing, and how does it work?

You’ve probably read stories about new research using the gene editing technique CRISPR, also called CRISPR/Cas9. The scientific world is captivated by this revolutionary technology, since it is easier, cheaper and more efficient than previous strategies for modifying DNA.

The term CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9. The names reflect important features …

Welcome to the CRISPR Zoo!

Nature  Sara Reardon 3/09/2016

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Timothy Doran’s 11-year-old daughter is allergic to eggs. And like about 2% of children worldwide who share the condition, she is unable to receive many routine vaccinations because they are produced using chicken eggs.

Doran, a molecular biologist at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) in Geelong, Australia, thinks that he could solve this problem using the powerful gene-editing tool CRISPR–Cas9. Most egg allergies are caused by one of …

CRISPR: The New Tool in the Gene Editing Revolution Explained

ABC Science By Bernie Hobbs Updated 11 Apr 2016, 11:03pm

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A powerful new gene-editing technology called CRISPR has enormous potential to treat human diseases but the ability to tinker with genes can also be controversial. Here we explain what CRISPR is and how it works.

Since gene technology first emerged over 40 years ago we’ve seen a wealth of genetic advances — not least of all the decoding of the human genome in 2001.

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